Hiding in an isolated cave, Jamie leads a lonely life until Lallybroch is threatened by redcoats pursuing the elusive Jacobite traitor known as "Red Jamie." Back in Boston, Claire and Frank struggle to coexist in a marriage haunted by the ghost of Jamie's love."
In prison, Jamie discovers that an old foe has become the warden - and now has the power to make his life a living hell. Over the years, Claire and Frank both put their best foot forward to share a harmonious marriage, but an uninvited guest shatters this illusion, bringing their differences to light.
While serving as groomsman at the aristocratic estate of Helwater, Jamie is reluctantly pulled into the intrigue of a noble British family. In 1968 Scotland, Claire, Brianna and Roger struggle to trace Jamie's whereabouts in history, leaving Claire to wonder if they will ever find him again.
As Brianna grapples with the life-changing revelations of the past summer, Claire must help her come to terms with the fact that she is truly her father's daughter - her 18th century Highlander father. To complicate matters further, Roger brings news that forces Claire and Brianna to face an impossible choice.
In the aftermath of a violent confrontation, Claire follows her conscience as a surgeon, even though it could put her and Jamie's lives at risk. At the same time, Jamie attempts to evade the reach of the Crown as its representative closes in on his illegal dealings.
Claire and Jamie leave Scotland, sailing to the West Indies on an urgent quest. But when the superstitious crew looks for someone to blame after a string of bad luck, rescue comes from an unlikely source.
Claire races to discover the source of an epidemic aboard a disease-stricken ship before hundreds of sailors die. And as Jamie locks horns with Captain Raines, Fergus finds himself torn between loyalty and love.
After making a leap of faith, Claire washes up on a seemingly deserted island where survival is her only option. Navigating treacherous waters has crippled the Artemis, so Jamie devises a joyful moment for his crew in the midst of devastating setbacks.
The Artemis finally reaches Jamaica bringing Jamie and Claire that much closer to their goal. During a lavish ball on the island, the Frasers encounter old allies, as well as former adversaries who threaten to derail their mission.