Claire is brought to Castle Leoch under suspicion as an English spy. Learning that the year is 1743, she tries to arrange travel back to the standing stones. Colum MacKenzie uses her ability as a healer as an excuse to detain her.
Claire's abilities as a healer puts her at odds with the town priest when she saves a boy's life, and deepens the suspicions against her. Hearing a folk-tale, Claire realizes that she may be able to travel back through the stones to Frank.
The Gathering shows Claire's attempt at her first real planned escape. The run-ins she has with various characters on the way include a major run-in with Dougal, and yet another moment with Jamie alone - building their relationship. Also an oath-taking ceremony could have awful results if not handled carefully.
Claire goes on the road with Dougal as he collects rents from the tenants. She meets the clans solicitor who is riding with them. She also becomes aware of Dougal's involvement in trying to raise money for the Jacobite rebellion.
Claire and Dougal are questioned at the local garrison, and Dougal is treated with hostility and disdain by the British occupiers. Claire lets down her guard, but her headstrong opinions get her into trouble again, and she discovers the true nature of Black Jack Randall when left alone with him.
Marriage to a Scot seems to be the only legal way out to save Claire from falling into the paws of Black Jack Randall. And Jamie accepts to become her husband and protect her. Claire is overwhelmed by circumstances that are forcing her into becoming an adulteress and a bigamist. The hasty marriage takes place and, in order to be legal, it must be consummated that night.
In 1945, Frank is still seeking Claire, but is starting to lose hope of ever finding her. Meanwhile in 1743, Claire is trying to come to terms with her marriage to Jamie. While traveling, a life changing opportunity arises.
Returning to her own time, Claire must reconcile her future with the life she left behind. Shifting back to the 18th century, Jamie, Claire and Murtagh arrive in France, but learn that Paris presents its own challenges.
Claire finds an outlet for her skills at L'Hôpital des Anges treating the sick, while Jamie tries to derail the Jacobite Rebellion with the help of a pickpocket. Claire's new relationship with Mother Hildegarde provides a source of needed help for Jamie.
Jamie has an unusual response to Claire's news, which brings about a confrontation. Louise asks Claire for assistance with a delicate situation, and friendly revelations provide disagreements at a dinner party with uninvited guests.
Jamie and Claire use Claire's medical knowledge to devise a scheme to stop a wine deal which could fill the Prince's war chest. When Claire learns Jamie has gone back on his word, the couple is met with dire consequences that will forever change their lives.
Claire and Jamie return to Scotland, and back to their home, Lallybroch. Away from the nightmares of Paris, they find solace until a letter arrives. Jamie must go and visit his grandfather Lord Lovat, Simon Fraser aka The Old Fox. Claire accompanies Jamie to meet The Old Fox.
Jamie trains his militia men for the upcoming Rising before joining the forces. Claire keeps to Jamie and gives him full disclosure on what little she knows about Scotland's fate in the Rising. Meanwhile, a young British soldier tries to kill Jamie.
Jamie needs to bypass a swamp to lead the Jacobite army to win over the British army in a critical battle. Benefiting from her experience as a combat nurse during WWII, Claire tends to wounded and dying warriors.
Claire and Highlanders are sent north after the Jacobite leaders decided to halt their march on London. A band of Redcoats makes trouble for the Scots, leading to the most unexpected reunion for Claire.
As Jamie puts all of his efforts into turning the Jacobite army away from the impending slaughter at Culloden Moor, Claire attempts to comfort the sick Alex Randall. She is stunned when Alex reveals an outrageous plan to save the mother of his child.
Flashing forward to 1968, Claire travels to Scotland with her twenty-year-old daughter, Brianna, and meets Roger Wakefield. Claire visits Lallybroch and Culloden Moor to make peace with the past, while Brianna and Roger bond over researching Randall family history. Claire finally reveals the truth to Brianna about her time travel through the stones, her life in 1700's Scotland, and Brianna's true parentage. The story is inter-cut with another one back in the 18th century, which happens on the day of the Battle of Culloden. When Jamie's last ditch attempts to deter The Prince fail, he and Claire come up with a dangerous plan - which Dougal overhears, inciting him to a murderous rage. Jamie must do everything he can to save the ones he loves, even if it means saying goodbye to some-or all-of them.
Hiding in an isolated cave, Jamie leads a lonely life until Lallybroch is threatened by redcoats pursuing the elusive Jacobite traitor known as "Red Jamie." Back in Boston, Claire and Frank struggle to coexist in a marriage haunted by the ghost of Jamie's love."
In prison, Jamie discovers that an old foe has become the warden - and now has the power to make his life a living hell. Over the years, Claire and Frank both put their best foot forward to share a harmonious marriage, but an uninvited guest shatters this illusion, bringing their differences to light.
While serving as groomsman at the aristocratic estate of Helwater, Jamie is reluctantly pulled into the intrigue of a noble British family. In 1968 Scotland, Claire, Brianna and Roger struggle to trace Jamie's whereabouts in history, leaving Claire to wonder if they will ever find him again.
As Brianna grapples with the life-changing revelations of the past summer, Claire must help her come to terms with the fact that she is truly her father's daughter - her 18th century Highlander father. To complicate matters further, Roger brings news that forces Claire and Brianna to face an impossible choice.
In the aftermath of a violent confrontation, Claire follows her conscience as a surgeon, even though it could put her and Jamie's lives at risk. At the same time, Jamie attempts to evade the reach of the Crown as its representative closes in on his illegal dealings.
Claire and Jamie leave Scotland, sailing to the West Indies on an urgent quest. But when the superstitious crew looks for someone to blame after a string of bad luck, rescue comes from an unlikely source.
Claire races to discover the source of an epidemic aboard a disease-stricken ship before hundreds of sailors die. And as Jamie locks horns with Captain Raines, Fergus finds himself torn between loyalty and love.
After making a leap of faith, Claire washes up on a seemingly deserted island where survival is her only option. Navigating treacherous waters has crippled the Artemis, so Jamie devises a joyful moment for his crew in the midst of devastating setbacks.
The Artemis finally reaches Jamaica bringing Jamie and Claire that much closer to their goal. During a lavish ball on the island, the Frasers encounter old allies, as well as former adversaries who threaten to derail their mission.